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Chronic Stress and the HPA Axis is areview of the current research behind hypothalamic-pituitary-adrenal (HPA) axis dysfunction. The paper discusses the stress response system, HPA axis dysfunction-related conditions, lab hormone assessment, hypercortisolism and hypocortisolism, and natural therapies. Glycemic control and supplementation of nutraceuticals such as DHEA, pregnenolone, phosphatidylserine, and adaptogenic herbs are also examined.