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The four key stressors affecting patient wellbeing are mental and emotional stress, glycemic dysregulation, inflammation, and sleep disturbance. These stressors interrupt the stress response system and can be debilitating for patients. The 4 Key Stressors Patient Questionnaire helps both patients and doctors identify the factors hindering the stress response. Questions such as, “Are you experiencing difficulty staying asleep?” or “Do you frequently experience anxiety?” prompt patients to consider their lifestyles and work with their doctors to develop a personalized protocol.